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Target
Alpha-2B adrenergic receptor
Ligand
BDBM50408199
Substrate
n/a
Meas. Tech.
ChEMBL_33508
Ki
2.5±n/a nM
Citation
 Elworthy, TR; Ford, AP; Bantle, GW; Morgans, DJ; Ozer, RS; Palmer, WS; Repke, DB; Romero, M; Sandoval, L; Sjogren, EB; Talamás, FX; Vazquez, A; Wu, H; Arredondo, NF; Blue, DR; DeSousa, A; Gross, LM; Kava, MS; Lesnick, JD; Vimont, RL; Williams, TJ; Zhu, QM; Pfister, JR; Clarke, DE N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists. J Med Chem 40:2674-87 (1997) [PubMed]  Article  BDB Entry
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADRA2B | Adrenergic receptor alpha | Adrenergic receptor alpha-2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | adrenergic Alpha2B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50379.83
Organism:
NEONATAL RAT
Description:
adrenergic Alpha2B ADRA2B NEONATAL RAT::P19328
Residue:
453
Sequence:
MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
  
Inhibitor
Name:
BDBM50408199
Synonyms:
CHEMBL88160
Type:
Small organic molecule
Emp. Form.:
C26H34F3N7O2
Mol. Mass.:
533.5891
SMILES:
CN(C)C(=O)c1cnc2n(C)nc(C)c2c1NCCCN1CCN(CC1)c1ccccc1OCC(F)(F)F
Structure:
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