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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50192800
Substrate
n/a
Meas. Tech.
ChEMBL_474247 (CHEMBL934096)
IC50
104.71±n/a nM
Citation
 Lee, JH; Kang, NS; Yoo, SE Docking-based 3D-QSAR study for 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 18:2479-90 (2008) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | 11-beta-HSD1 | 11-DH | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | DHI1_HUMAN | HSD11B1 | HSD11 | HSD11L | SDR26C1 | 11-beta-hydroxysteroid dehydrogenase
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Human
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50192800
Synonyms:
2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5-yl-adamantan-2-yl)-2-methyl-propionamide | CHEMBL219428
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@@](c1ccno1)(C2)C3
Structure:
Search PDB for entries with ligand similarity: