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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50417839
Substrate
n/a
Meas. Tech.
ChEMBL_718092
EC50
794.33±n/a nM
Citation
 Trabanco, AA; Duvey, G; Cid, JM; Macdonald, GJ; Cluzeau, P; Nhem, V; Furnari, R; Behaj, N; Poulain, G; Finn, T; Lavreysen, H; Poli, S; Raux, A; Thollon, Y; Poirier, N; D'Addona, D; Andrés, JI; Lutjens, R; Le Poul, E; Imogai, H; Rocher, JP New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones. Bioorg Med Chem Lett 21:971-6 (2011) [PubMed]  Article  BDB Entry
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | mGluR2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50417839
Synonyms:
CHEMBL1669389
Type:
Small organic molecule
Emp. Form.:
C21H22ClN3O2
Mol. Mass.:
383.871
SMILES:
CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(nc1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: