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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM10759
Substrate
n/a
Meas. Tech.
ChEMBL_842055 (CHEMBL2091472)
EC50
3120±n/a nM
Citation
 Zanaletti, R; Bettinetti, L; Castaldo, C; Cocconcelli, G; Comery, T; Dunlop, J; Gaviraghi, G; Ghiron, C; Haydar, SN; Jow, F; Maccari, L; Micco, I; Nencini, A; Scali, C; Turlizzi, E; Valacchi, M Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). J Med Chem 55:4806-23 (2012) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | Neuronal acetylcholine receptor | ACHA7_RAT | Chrna7 | Acra7
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rat
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM10759
Synonyms:
2-acetoxyethyl(trimethyl)ammonium;perchlorate | 2-acetoxyethyl(trimethyl)ammonium;bromide | acetylcholine chloride | cid_6060 | CHEMBL667 | [2-(acetyloxy)ethyl]trimethylazanium | acetylcholine | US10667515, Compound ACh
Type:
Small Organic Molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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