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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50424387
Substrate
n/a
Meas. Tech.
ChEMBL_935622 (CHEMBL2320404)
Kd
447±n/a nM
Citation
Downey, JD; Saleh, SA; Bridges, TM; Morrison, RD; Scott Daniels, J; Lindsley, CW; Breyer, RM Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere. Bioorg Med Chem Lett 23:37-41 (2012) [PubMed] Article
More Info.:
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:
G-protein coupled receptor
Mol. Mass.:
43000.62
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL