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Target
Hematopoietic prostaglandin D synthase
Ligand
BDBM50425313
Substrate
n/a
Meas. Tech.
ChEMBL_933829 (CHEMBL2321383)
IC50
>10000±n/a nM
Citation
 Kablaoui, N; Patel, S; Shao, J; Demian, D; Hoffmaster, K; Berlioz, F; Vazquez, ML; Moore, WM; Nugent, RA Novel benzoxazole inhibitors of mPGES-1. Bioorg Med Chem Lett 23:907-11 (2013) [PubMed]  Article 
Target
Name:
Hematopoietic prostaglandin D synthase
Synonyms:
Hematopoietic prostaglandin D synthase | Hematopoietic prostaglandin D synthase (HPGDS) | H-PGDS | Glutathione-requiring prostaglandin D synthase | Hematopoietic prostaglandin D synthase (H-PGDS) | Prostaglandin D | Glutathione-dependent PGD synthetase | HPGDS_HUMAN | HPGDS | GSTS | PGDS | PTGDS2 | Prostaglandin D Synthase
Type:
Enzyme
Mol. Mass.:
23341.07
Organism:
Human
Description:
The protein was expressed in E. coli strain BL21(DE3) with an N-terminal 6-His tag.
Residue:
199
Sequence:
MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
  
Inhibitor
Name:
BDBM50425313
Synonyms:
CHEMBL2315853
Type:
Small organic molecule
Emp. Form.:
C25H28ClN3O3
Mol. Mass.:
453.96
SMILES:
Clc1ccc2oc(nc2c1)N1CCC(CC1)C(=O)N[C@H]1CCC[C@@H]1OCc1ccccc1 |r|
Structure:
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