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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM90787
Substrate
n/a
Meas. Tech.
ChEMBL_935189 (CHEMBL2317558)
IC50
12500±n/a nM
Citation
 Sindelar, M; Lutz, TA; Petrera, M; Wanner, KT Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward¿-aminobutyric acid transporter 1. J Med Chem 56:1323-40 (2013) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter 1 | SC6A1_MOUSE | Slc6a1 | Gabt1 | Gat-1 | Gat1 | GABA transporter
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Mouse
Description:
ChEMBL_788602
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
  
Inhibitor
Name:
BDBM90787
Synonyms:
SMR000326834 | cid_11957555 | GUVACINE | MLS000859975 | Guvacine hydrochloride | 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.06
SMILES:
OC(=O)C1=CCCNC1 |t:3|
Structure:
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