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Target
D-aspartate oxidase
Ligand
BDBM50146456
Substrate
n/a
Meas. Tech.
ChEMBL_938789 (CHEMBL2327933)
IC50
>10000000±n/a nM
Citation
 Katane, M; Osaka, N; Matsuda, S; Maeda, K; Kawata, T; Saitoh, Y; Sekine, M; Furuchi, T; Doi, I; Hirono, S; Homma, H Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro. J Med Chem 56:1894-907 (2013) [PubMed]  Article 
Target
Name:
D-aspartate oxidase
Synonyms:
DASOX | OXDD_HUMAN | DDO | D-Aspartate Oxidase (DDO)
Type:
Oxidoreductase
Mol. Mass.:
37543.06
Organism:
Human
Description:
Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:
341
Sequence:
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
  
Inhibitor
Name:
BDBM50146456
Synonyms:
(2E)-3-(3-hydroxyphenyl)prop-2-enoic acid | trans-3-coumaric acid | (2E)-3-(3-hydroxyphenyl)-2-propenoic acid | (2E)-3-(3-hydroxyphenyl)acrylic acid | (E)-3-(3-hydroxyphenyl)-2-propenoic acid | 3-Coumaric acid | trans-3-Hydroxycinnamate | CHEMBL98521
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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