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Target
SH2 domain-containing protein 1A
Ligand
BDBM50427872
Substrate
n/a
Meas. Tech.
ChEMBL_940846 (CHEMBL2330426)
IC50
17000±n/a nM
Citation
 Chu, CY; Chang, CP; Chou, YT; Handoko, na; Hu, YL; Lo, LC; Lin, JJ Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein. J Med Chem 56:2841-9 (2013) [PubMed]  Article 
Target
Name:
SH2 domain-containing protein 1A
Synonyms:
Duncan disease SH2-protein | SLAM-associated protein | Signaling lymphocytic activation molecule-associated protein | T-cell signal transduction molecule SAP | SH21A_HUMAN | SH2D1A | DSHP | SAP
Type:
PROTEIN
Mol. Mass.:
14191.56
Organism:
Human
Description:
ChEMBL_940846
Residue:
128
Sequence:
MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP
  
Inhibitor
Name:
BDBM50427872
Synonyms:
CHEMBL2326990
Type:
Small organic molecule
Emp. Form.:
C29H28N3O10P
Mol. Mass.:
609.52
SMILES:
NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc2OP(O)(=O)OCc2c1)NC(=O)OCC1c2ccccc2-c2ccccc12 |r|
Structure:
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