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Target
Arginase-2, mitochondrial
Ligand
BDBM50427899
Substrate
n/a
Meas. Tech.
ChEMBL_940978 (CHEMBL2330668)
IC50
67±n/a nM
Citation
 Van Zandt, MC; Whitehouse, DL; Golebiowski, A; Ji, MK; Zhang, M; Beckett, RP; Jagdmann, GE; Ryder, TR; Sheeler, R; Andreoli, M; Conway, B; Mahboubi, K; D'Angelo, G; Mitschler, A; Cousido-Siah, A; Ruiz, FX; Howard, EI; Podjarny, AD; Schroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem 56:2568-80 (2013) [PubMed]  Article 
Target
Name:
Arginase-2, mitochondrial
Synonyms:
Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase | ARGI2_HUMAN | ARG2
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Human
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
  
Inhibitor
Name:
BDBM50427899
Synonyms:
CHEMBL2326090
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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