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Target
Arginase-1
Ligand
BDBM50427900
Substrate
n/a
Meas. Tech.
ChEMBL_940977
IC50
3000±n/a nM
Citation
 Van Zandt, MC; Whitehouse, DL; Golebiowski, A; Ji, MK; Zhang, M; Beckett, RP; Jagdmann, GE; Ryder, TR; Sheeler, R; Andreoli, M; Conway, B; Mahboubi, K; D'Angelo, G; Mitschler, A; Cousido-Siah, A; Ruiz, FX; Howard, EI; Podjarny, AD; Schroeter, H Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem 56:2568-80 (2013) [PubMed]  Article
Target
Name:
Arginase-1
Synonyms:
ARG1 | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50427900
Synonyms:
(R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]hexanoic acid (ABH-PE) | CHEMBL2326089
Type:
Small organic molecule
Emp. Form.:
C13H27BN2O4
Mol. Mass.:
286.175
SMILES:
N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O |r|
Structure:
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