Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50026603
Substrate
n/a
Meas. Tech.
ChEMBL_947794 (CHEMBL2342213)
IC50
8.1±n/a nM
Citation
 Greedy, BM; Bradbury, F; Thomas, MP; Grivas, K; Cami-Kobeci, G; Archambeau, A; Bosse, K; Clark, MJ; Aceto, M; Lewis, JW; Traynor, JR; Husbands, SM Orvinols with mixed kappa/mu opioid receptor agonist activity. J Med Chem 56:3207-16 (2013) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50026603
Synonyms:
Buprenorphine | CHEBI:3216
Type:
Small organic molecule
Emp. Form.:
C29H41NO4
Mol. Mass.:
467.6401
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@](C)(O)C(C)(C)C)ccc3O |r,TLB:25:17:4.5.6:9.15.14,18:17:4.5.6:9.15.14,THB:10:9:17:4.5.6,3:4:17:9.15.14,26:23:16.1:18.19|
Structure:
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