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Target
Histamine H3 receptor
Ligand
BDBM50433198
Substrate
n/a
Meas. Tech.
ChEMBL_957095 (CHEMBL2378560)
Ki
6.3±n/a nM
Citation
 Labeeuw, O; Levoin, N; Poupardin-Olivier, O; Calmels, T; Ligneau, X; Berrebi-Bertrand, I; Robert, P; Lecomte, JM; Schwartz, JC; Capet, M Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile. Bioorg Med Chem Lett 23:2548-54 (2013) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_MOUSE | Hrh3
Type:
PROTEIN
Mol. Mass.:
48560.37
Organism:
Mus musculus
Description:
ChEMBL_988451
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVETGEAGLGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50433198
Synonyms:
CHEMBL2375588
Type:
Small organic molecule
Emp. Form.:
C21H33NO2
Mol. Mass.:
331.4922
SMILES:
OC1CCC(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |(69.59,-45.6,;68.26,-44.82,;66.92,-45.58,;65.59,-44.81,;65.6,-43.27,;64.27,-42.5,;62.93,-43.27,;62.93,-44.81,;61.59,-45.58,;60.27,-44.8,;58.93,-45.56,;57.6,-44.79,;56.26,-45.56,;54.93,-44.78,;53.6,-45.55,;52.27,-44.77,;50.94,-45.55,;50.94,-47.09,;52.27,-47.85,;53.6,-47.09,;60.26,-43.27,;61.59,-42.5,;66.93,-42.5,;68.26,-43.28,)|
Structure:
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