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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50056272
Substrate
n/a
Meas. Tech.
ChEMBL_959165 (CHEMBL2383346)
IC50
5.6±n/a nM
Citation
 Monn, JA; Valli, MJ; Massey, SM; Hao, J; Reinhard, MR; Bures, MG; Heinz, BA; Wang, X; Carter, JH; Getman, BG; Stephenson, GA; Herin, M; Catlow, JT; Swanson, S; Johnson, BG; McKinzie, DL; Henry, SS Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem 56:4442-55 (2013) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | GRM2_HUMAN | GRM2 | GPRC1B | MGLUR2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Human
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50056272
Synonyms:
(2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(LY354740) | LY366563 | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | LY-354740 | CHEMBL8759 | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N
Structure:
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