Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50434193
Substrate
n/a
Meas. Tech.
ChEMBL_960925 (CHEMBL2388543)
EC50
3780±n/a nM
Citation
 Wang, Y; Liu, JJ; Dransfield, PJ; Zhu, L; Wang, Z; Du, X; Jiao, X; Su, Y; Li, AR; Brown, SP; Kasparian, A; Vimolratana, M; Yu, M; Pattaropong, V; Houze, JB; Swaminath, G; Tran, T; Nguyen, K; Guo, Q; Zhang, J; Zhuang, R; Li, F; Miao, L; Bartberger, MD; Correll, TL; Chow, D; Wong, S; Luo, J; Lin, DC; Medina, JC Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles. ACS Med Chem Lett 4:551-5 (2013) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50434193
Synonyms:
CHEMBL2385467
Type:
Small organic molecule
Emp. Form.:
C33H33FO4
Mol. Mass.:
512.6111
SMILES:
COc1ccc(F)c(c1)-c1ccc(COc2ccc3CC[C@@]4(C[C@H]4C(O)=O)c3c2)cc1C1=CCCC1(C)C |r,t:36|
Structure:
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