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Target
Sodium- and chloride-dependent GABA transporter 3
Ligand
BDBM50039246
Substrate
n/a
Meas. Tech.
ChEMBL_976653 (CHEMBL2417028)
IC50
1120±n/a nM
Citation
Nakada, K; Yoshikawa, M; Ide, S; Suemasa, A; Kawamura, S; Kobayashi, T; Masuda, E; Ito, Y; Hayakawa, W; Katayama, T; Yamada, S; Arisawa, M; Minami, M; Shuto, S Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports. Bioorg Med Chem 21:4938-50 (2013) [PubMed] Article
More Info.:
Target
Name:
Sodium- and chloride-dependent GABA transporter 3
Synonyms:
GABA transporter 3 | GABT3 | GAT-3 | GAT3 | S6A11_HUMAN | SLC6A11 | Solute carrier family 6 member 11
Type:
PROTEIN
Mol. Mass.:
70607.60
Organism:
Human
Description:
ChEMBL_1454198
Residue:
632
Sequence:
MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
Inhibitor
Name:
BDBM50039246
Synonyms:
(S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid | (S)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid | CHEMBL75035
Type:
Small organic molecule
Emp. Form.:
C30H35NO6
Mol. Mass.:
505.602
SMILES:
COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |r|