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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50000102
Substrate
n/a
Meas. Tech.
ChEMBL_976654 (CHEMBL2417029)
IC50
209000±n/a nM
Citation
 Nakada, K; Yoshikawa, M; Ide, S; Suemasa, A; Kawamura, S; Kobayashi, T; Masuda, E; Ito, Y; Hayakawa, W; Katayama, T; Yamada, S; Arisawa, M; Minami, M; Shuto, S Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports. Bioorg Med Chem 21:4938-50 (2013) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter 2 | GAT2 | S6A13_HUMAN | SLC6A13
Type:
PROTEIN
Mol. Mass.:
68012.63
Organism:
Human
Description:
ChEMBL_1454197
Residue:
602
Sequence:
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
  
Inhibitor
Name:
BDBM50000102
Synonyms:
3-aminopropanoic acidbeta-alanine | Alanine-beta | CHEMBL297569 | beta-alanine | beta-aminopropionic acid | omega-aminopropionic acid
Type:
Small organic molecule
Emp. Form.:
C3H7NO2
Mol. Mass.:
89.0932
SMILES:
NCCC(O)=O
Structure:
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