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Target
Toll-like receptor 8
Ligand
BDBM50440284
Substrate
n/a
Meas. Tech.
ChEMBL_982411 (CHEMBL2427222)
EC50
9000±n/a nM
Citation
 Roethle, PA; McFadden, RM; Yang, H; Hrvatin, P; Hui, H; Graupe, M; Gallagher, B; Chao, J; Hesselgesser, J; Duatschek, P; Zheng, J; Lu, B; Tumas, DB; Perry, J; Halcomb, RL Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis. J Med Chem 56:7324-33 (2013) [PubMed]  Article 
Target
Name:
Toll-like receptor 8
Synonyms:
CD_antigen: CD288 | TRL8 | TLR8_HUMAN | TLR8
Type:
Enzyme
Mol. Mass.:
119828.77
Organism:
Human
Description:
Q9NR97
Residue:
1041
Sequence:
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY
  
Inhibitor
Name:
BDBM50440284
Synonyms:
CHEMBL2424780 | US9708325, GS-9620 | US10457681, Compound Vesatolimod | US10508115, Compound Vesatolimod | US10487084, Compound Vesatolimod | US10654856, GS-9620 | US10919895, Vesatolimod | US10981914, Compound Vesatolimod | US11242345, Example GS-9620
Type:
Small organic molecule
Emp. Form.:
C22H30N6O2
Mol. Mass.:
410.51
SMILES:
CCCCOc1nc(c2c(n1)N(CC(=O)N2)Cc3cccc(c3)CN4CCCC4)N
Structure:
Search PDB for entries with ligand similarity: