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Target
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-2
Ligand
BDBM50441458
Substrate
n/a
Meas. Tech.
ChEMBL_988318 (CHEMBL2439884)
Ki
>10000±n/a nM
Citation
 Dukat, M; Alix, K; Worsham, J; Khatri, S; Schulte, MK 2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character. Bioorg Med Chem Lett 23:5945-8 (2013) [PubMed]  Article 
Target
Name:
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-2
Synonyms:
Nicotinic acetylcholine receptor alpha2/beta2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 964980
Components:
This complex has 2 components.
Component 1
Name:
Acetylcholine receptor subunit alpha
Synonyms:
Acetylcholine receptor subunit alpha | n-AChR | Acetylcholine receptor protein alpha chain | Nicotinic acetylcholine receptor alpha2/beta4 | Cholinergic, Nicotinic Alpha1Beta1DeltaGamma | Cholinergic, Nicotinic Alpha1Beta2 | ACHA_HUMAN | CHRNA1 | ACHRA | CHNRA | Nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon | Nicotinic acetylcholine receptor alpha-1/beta-1 | alpha-1 Nicotinic AChR
Type:
Ion channel
Mol. Mass.:
54542.01
Organism:
Human
Description:
n/a
Residue:
482
Sequence:
MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
  
Component 2
Name:
Neuronal acetylcholine receptor subunit beta-2
Synonyms:
Neuronal acetylcholine receptor protein beta-2 subunit | Nicotinic acetylcholine receptor alpha3/beta2/alpha5 | ACHB2_HUMAN | CHRNB2
Type:
Protein
Mol. Mass.:
57020.50
Organism:
Human
Description:
P17787
Residue:
502
Sequence:
MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
  
Inhibitor
Name:
BDBM50441458
Synonyms:
CHEMBL2436555
Type:
Small organic molecule
Emp. Form.:
C8H9Cl2N3
Mol. Mass.:
218.08
SMILES:
NC1=NCc2cc(Cl)ccc2N1 |t:1|
Structure:
Search PDB for entries with ligand similarity: