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Target
Perforin-1
Ligand
BDBM50445254
Substrate
n/a
Meas. Tech.
ChEMBL_1285138 (CHEMBL3106784)
IC50
2550±n/a nM
Citation
 Spicer, JA; Lena, G; Lyons, DM; Huttunen, KM; Miller, CK; O'Connor, PD; Bull, M; Helsby, N; Jamieson, SM; Denny, WA; Ciccone, A; Browne, KA; Lopez, JA; Rudd-Schmidt, J; Voskoboinik, I; Trapani, JA Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem 56:9542-55 (2014) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50445254
Synonyms:
CHEMBL3103641
Type:
Small organic molecule
Emp. Form.:
C22H16N4O2S
Mol. Mass.:
400.453
SMILES:
O=C1NC(=S)C(N1)=Cc1ccc2cc(ccc2n1)-c1ccc2C(=O)NCCc2c1 |w:7.8|
Structure:
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