Target
Perforin-1
Ligand
BDBM50445266
Substrate
n/a
Meas. Tech.
ChEMBL_1285138 (CHEMBL3106784)
IC50
2330±n/a nM
Citation
 Spicer, JALena, GLyons, DMHuttunen, KMMiller, CKO'Connor, PDBull, MHelsby, NJamieson, SMDenny, WACiccone, ABrowne, KALopez, JARudd-Schmidt, JVoskoboinik, ITrapani, JA Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin. J Med Chem 56:9542-55 (2014) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50445266
Synonyms:
CHEMBL3103648
Type:
Small organic molecule
Emp. Form.:
C18H15N3O2S2
Mol. Mass.:
369.461
SMILES:
CN1CCc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1
Structure:
Search PDB for entries with ligand similarity: