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Target
Platelet-derived growth factor subunit A
Ligand
BDBM99471
Substrate
n/a
Meas. Tech.
ChEMBL_1296291 (CHEMBL3132619)
IC50
610±n/a nM
Citation
 Okaniwa, M; Hirose, M; Arita, T; Yabuki, M; Nakamura, A; Takagi, T; Kawamoto, T; Uchiyama, N; Sumita, A; Tsutsumi, S; Tottori, T; Inui, Y; Sang, BC; Yano, J; Aertgeerts, K; Yoshida, S; Ishikawa, T Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives. J Med Chem 56:6478-94 (2013) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor subunit A
Synonyms:
PDGF subunit A | PDGF-1 | Platelet-derived growth factor A chain | Platelet-derived growth factor alpha polypeptide | PDGFA_HUMAN | PDGFA | PDGF1
Type:
PROTEIN
Mol. Mass.:
24060.81
Organism:
Human
Description:
ChEMBL_108150
Residue:
211
Sequence:
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT
  
Inhibitor
Name:
BDBM99471
Synonyms:
US8497274, 32 | US12440494, Compound TAK-632
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1cc(cc(c1)C(F)(F)F)CC(=O)Nc2cc(ccc2F)Oc3ccc4c(c3C#N)sc(n4)NC(=O)C5CC5
Structure:
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