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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM82505
Substrate
n/a
Meas. Tech.
ChEMBL_1297283 (CHEMBL3132069)
Kd
0.020000±n/a nM
Citation
 Caillé, F; Morley, TJ; Tavares, AA; Papin, C; Twardy, NM; Alagille, D; Lee, HS; Baldwin, RM; Seibyl, JP; Barret, O; Tamagnan, GD Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699. Bioorg Med Chem Lett 23:6243-7 (2013) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43735.29
Organism:
GUINEA PIG
Description:
5-HT4 HTR4 GUINEA PIG::O70528
Residue:
388
Sequence:
MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
  
Inhibitor
Name:
BDBM82505
Synonyms:
CAS_121881 | NSC_121881 | SB204070
Type:
Small organic molecule
Emp. Form.:
C19H27ClN2O4
Mol. Mass.:
382.882
SMILES:
CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Structure:
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