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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM86248
Substrate
n/a
Meas. Tech.
ChEMBL_1296518 (CHEMBL3130657)
Kd
230000±n/a nM
Citation
 Giannetti, AM; Zheng, X; Skelton, NJ; Wang, W; Bravo, BJ; Bair, KW; Baumeister, T; Cheng, E; Crocker, L; Feng, Y; Gunzner-Toste, J; Ho, YC; Hua, R; Liederer, BM; Liu, Y; Ma, X; O'Brien, T; Oeh, J; Sampath, D; Shen, Y; Wang, C; Wang, L; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhao, G; Zhao, Q; Dragovich, PS Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem 57:770-92 (2014) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1 | NAmPRTase | Nicotinamide phosphoribosyltransferase | NAMPT_HUMAN | NAMPT | PBEF | PBEF1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Human
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM86248
Synonyms:
NSC_3019 | CAS_364-98-7 | diazoxide
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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