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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50001308
Substrate
n/a
Meas. Tech.
ChEMBL_1335505 (CHEMBL3239290)
IC50
0.700000±n/a nM
Citation
 Graham, TH; Shu, M; Verras, A; Chen, Q; Garcia-Calvo, M; Li, X; Lisnock, J; Tong, X; Tung, EC; Wiltsie, J; Hale, JJ; Pinto, S; Shen, DM Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett 24:1657-60 (2014) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Proline carboxypeptidase | Prolylcarboxypeptidase | PCP_MOUSE | Prcp
Type:
PROTEIN
Mol. Mass.:
55028.96
Organism:
Mouse
Description:
ChEMBL_1335505
Residue:
491
Sequence:
MGCRALLLLSFLLLGAATTIPPRLKTLGSPHLSASPTPDPAVARKYSVLYFEQKVDHFGFADMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTIPGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTNDFRKSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCQYLKNPNVSDTVLLQNIFQALSVYYNYSGQAACLNISQTTTSSLGSMGWSFQACTEMVMPFCTNGIDDMFEPFLWDLEKYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGELDPWSGGGVTRDITDTLVAINIHDGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWILDFYSNIQ
  
Inhibitor
Name:
BDBM50001308
Synonyms:
CHEMBL3237393
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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