Target
D(2) dopamine receptor
Ligand
BDBM50003071
Substrate
n/a
Meas. Tech.
ChEMBL_1335160 (CHEMBL3239709)
Ki
240±n/a nM
Citation
 Xiao, JFree, RBBarnaeva, EConroy, JLDoyle, TMiller, BBryant-Genevier, MTaylor, MKHu, XDulcey, AESouthall, NFerrer, MTitus, SZheng, WSibley, DRMarugan, JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem 57:3450-63 (2014) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Human
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50003071
Synonyms:
CHEMBL3234541
Type:
Small organic molecule
Emp. Form.:
C22H17BrN2O3S
Mol. Mass.:
469.351
SMILES:
CN1c2cc(ccc2[S@@+]([O-])c2ccccc2C1=O)C(=O)NCc1ccc(Br)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: