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Target
Translocator protein
Ligand
BDBM50011484
Substrate
n/a
Meas. Tech.
ChEMBL_1352881 (CHEMBL3269398)
Ki
0.235000±n/a nM
Citation
 Castellano, S; Taliani, S; Viviano, M; Milite, C; Da Pozzo, E; Costa, B; Barresi, E; Bruno, A; Cosconati, S; Marinelli, L; Greco, G; Novellino, E; Sbardella, G; Da Settimo, F; Martini, C Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors. J Med Chem 57:2413-28 (2014) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50011484
Synonyms:
CHEMBL3261894
Type:
Small organic molecule
Emp. Form.:
C24H20ClN3O
Mol. Mass.:
401.888
SMILES:
CCN(Cc1ccccc1)C(=O)c1nc(-c2ccccc2Cl)c2ccccc2n1
Structure:
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