Target
Nuclear receptor ROR-gamma
Ligand
BDBM50012136
Substrate
n/a
Meas. Tech.
ChEMBL_1351781 (CHEMBL3270932)
IC50
5400±n/a nM
Citation
 Fauber, BPRené, OBurton, BEverett, CGobbi, AHawkins, JJohnson, ARLiimatta, MLockey, PNorman, MWong, H Identification of tertiary sulfonamides as RORc inverse agonists. Bioorg Med Chem Lett 24:2182-7 (2014) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50012136
Synonyms:
CHEMBL3263702
Type:
Small organic molecule
Emp. Form.:
C23H28N2O2S2
Mol. Mass.:
428.611
SMILES:
CC(C)CN(Cc1ccc(s1)-c1ccc(CN)cc1)S(=O)(=O)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: