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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50017307
Substrate
n/a
Meas. Tech.
ChEMBL_1362418 (CHEMBL3292526)
IC50
0.019953±n/a nM
Citation
 De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem 57:4661-76 (2014) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:
Protein
Mol. Mass.:
83318.87
Organism:
Homo sapiens (Human)
Description:
Q07343
Residue:
736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
  
Inhibitor
Name:
BDBM50017307
Synonyms:
CHEMBL3287994
Type:
Small organic molecule
Emp. Form.:
C37H40FN5O5
Mol. Mass.:
653.7424
SMILES:
Cc1cccc(n1)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCCOCC1 |r,wU:10.10,13.17,(21.13,-24.41,;19.8,-23.64,;19.81,-22.1,;18.47,-21.33,;17.14,-22.1,;17.15,-23.63,;18.47,-24.4,;15.82,-24.4,;15.82,-25.94,;14.49,-23.62,;13.14,-24.4,;13.14,-25.94,;11.81,-26.71,;10.47,-25.93,;10.47,-24.4,;11.81,-23.62,;9.14,-26.71,;7.8,-25.94,;7.8,-24.4,;6.47,-26.72,;5.13,-25.96,;3.8,-26.72,;2.46,-25.96,;3.8,-28.27,;5.14,-29.05,;6.48,-28.27,;7.81,-29.04,;7.81,-30.58,;6.48,-31.35,;6.48,-32.89,;7.82,-33.67,;9.16,-32.88,;9.15,-31.34,;10.49,-33.64,;10.5,-35.19,;11.83,-35.95,;13.17,-35.17,;14.51,-35.93,;13.15,-33.62,;11.81,-32.86,;11.8,-31.32,;13.13,-30.54,;13.01,-29.01,;14.13,-27.96,;15.65,-28.17,;16.43,-29.49,;15.88,-30.93,;14.41,-31.4,)|
Structure:
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