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Target
Adenosylhomocysteinase
Ligand
BDBM50088426
Substrate
n/a
Meas. Tech.
ChEMBL_1362082 (CHEMBL3294635)
IC50
303±n/a nM
Citation
 Converso, A; Hartingh, T; Fraley, ME; Garbaccio, RM; Hartman, GD; Huang, SY; Majercak, JM; McCampbell, A; Na, SJ; Ray, WJ; Savage, MJ; Wolffe, C; Yeh, S; Yu, Y; White, R; Zhang, R Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett 24:2737-40 (2014) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | SAHH_HUMAN | AHCY | SAHH
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Human
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50088426
Synonyms:
3-(6-Amino-purin-9-yl)-5-hydroxymethyl-cyclopentane-1,2-diol | (1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol | CHEMBL49935
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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