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Target
Polyunsaturated fatty acid lipoxygenase ALOX12
Ligand
BDBM50020584
Substrate
n/a
Meas. Tech.
ChEMBL_1361570 (CHEMBL3295137)
IC50
7700±n/a nM
Citation
 Koeberle, A; Muñoz, E; Appendino, GB; Minassi, A; Pace, S; Rossi, A; Weinigel, C; Barz, D; Sautebin, L; Caprioglio, D; Collado, JA; Werz, O SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem 57:5638-48 (2014) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:
Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | 12-LOX | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 | LOX12_HUMAN | ALOX12 | 12LO | LOG12 | 12-Lipoxygenase (12-LOX)
Type:
Protein
Mol. Mass.:
75689.18
Organism:
Human
Description:
P18054
Residue:
663
Sequence:
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI
  
Inhibitor
Name:
BDBM50020584
Synonyms:
CHEMBL2413471
Type:
Small organic molecule
Emp. Form.:
C19H18N2O4
Mol. Mass.:
338.13
SMILES:
COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O
Structure:
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