Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50027942
Substrate
n/a
Meas. Tech.
ChEMBL_1436858
EC50
12±n/a nM
Citation
 Horan, JC; Sanyal, S; Choi, Y; Hill-Drzewi, M; Patnaude, L; Anderson, S; Fogal, S; Mao, C; Cook, BN; Gueneva-Boucheva, K; Fisher, MB; Hickey, E; Pack, E; Bannen, LC; Chan, DS; Mac, MB; Ng, SM; Wang, Y; Xu, W; Modis, LK; Lemieux, RM Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists. Bioorg Med Chem Lett 24:4807-11 (2014) [PubMed]  Article  BDB Entry
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50027942
Synonyms:
CHEMBL3344423
Type:
Small organic molecule
Emp. Form.:
C22H22Cl2FN5O4
Mol. Mass.:
510.346
SMILES:
N[C@@H](CO)COc1cc(Cl)c(cc1F)-c1noc(n1)N1CCN(CC1)C(=O)c1cccc(Cl)c1 |r|
Structure:
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