Target
G-protein coupled receptor 39
Ligand
BDBM50030774
Substrate
n/a
Meas. Tech.
ChEMBL_1438503 (CHEMBL3384907)
EC50
1.000000±n/a nM
Citation
 Peukert, SHughes, RNunez, JHe, GYan, ZJain, RLlamas, LLuchansky, SCarlson, ALiang, GKunjathoor, VPietropaolo, MShapiro, JCastellana, AWu, XBose, A Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett 5:1114-8 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 39
Synonyms:
GPR39 | GPR39_HUMAN
Type:
PROTEIN
Mol. Mass.:
51351.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107977
Residue:
453
Sequence:
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
  
Inhibitor
Name:
BDBM50030774
Synonyms:
CHEMBL3342379
Type:
Small organic molecule
Emp. Form.:
C19H19FN6O
Mol. Mass.:
366.3922
SMILES:
CNc1nc(NCc2ccc(NC(C)=O)cc2F)cc(n1)-c1ccccn1
Structure:
Search PDB for entries with ligand similarity: