Target
G-protein coupled receptor 39
Ligand
BDBM50030769
Substrate
n/a
Meas. Tech.
ChEMBL_1438503 (CHEMBL3384907)
EC50
22000±n/a nM
Citation
 Peukert, SHughes, RNunez, JHe, GYan, ZJain, RLlamas, LLuchansky, SCarlson, ALiang, GKunjathoor, VPietropaolo, MShapiro, JCastellana, AWu, XBose, A Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett 5:1114-8 (2014) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 39
Synonyms:
GPR39 | GPR39_HUMAN
Type:
PROTEIN
Mol. Mass.:
51351.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107977
Residue:
453
Sequence:
MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV
  
Inhibitor
Name:
BDBM50030769
Synonyms:
CHEMBL3342363
Type:
Small organic molecule
Emp. Form.:
C13H14N4
Mol. Mass.:
226.2771
SMILES:
C(Nc1cc(ncn1)-c1ccccn1)C1CC1
Structure:
Search PDB for entries with ligand similarity: