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Target
Cathepsin S
Ligand
BDBM50030823
Substrate
n/a
Meas. Tech.
ChEMBL_1438541 (CHEMBL3385531)
IC50
7.7±n/a nM
Citation
 Jadhav, PK; Schiffler, MA; Gavardinas, K; Kim, EJ; Matthews, DP; Staszak, MA; Coffey, DS; Shaw, BW; Cassidy, KC; Brier, RA; Zhang, Y; Christie, RM; Matter, WF; Qing, K; Durbin, JD; Wang, Y; Deng, GG Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett 5:1138-42 (2014) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50030823
Synonyms:
CHEMBL3342553
Type:
Small organic molecule
Emp. Form.:
C25H29FN4O5
Mol. Mass.:
484.52
SMILES:
CNC(=O)O[C@H]1COc2ccc(cc2[C@@H]1NC(=O)c1ccc(F)cc1)N1CCN(CC1)C1COC1 |r|
Structure:
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