Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50032890
Substrate
n/a
Meas. Tech.
ChEMBL_1431796 (CHEMBL3385092)
EC50
<1.000000±n/a nM
Citation
 Abdel-Magid, AF Neutrophil elastase inhibitors as potential anti-inflammatory therapies. ACS Med Chem Lett 5:1182-3 (2014) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50032890
Synonyms:
CHEMBL3342780
Type:
Small organic molecule
Emp. Form.:
C25H20F2N4O5S
Mol. Mass.:
526.512
SMILES:
CS(=O)(=O)c1cc(ccc1C1N(C(=O)N2CC2)C(=O)N(C2=C1C(=O)CC2)c1cccc(c1)C(F)F)C#N |c:22|
Structure:
Search PDB for entries with ligand similarity: