Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50041182
Substrate
n/a
Meas. Tech.
ChEMBL_1445730 (CHEMBL3374867)
Ki
1400±n/a nM
Citation
 Kriegl, JM; Martyres, D; Grundl, MA; Anderskewitz, R; Dollinger, H; Rast, G; Schmid, B; Seither, P; Tautermann, CS Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model. Bioorg Med Chem Lett 25:229-35 (2014) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
CCR3_RAT | Ccr3 | Cmkbr3
Type:
PROTEIN
Mol. Mass.:
41648.91
Organism:
Rattus norvegicus
Description:
ChEMBL_1445730
Residue:
359
Sequence:
MASNEEELKTVVETFETTPYEYEWAPPCEKVSIRELGSWLLPPLYSLVFIVGLLGNMMVVLILIKYRKLQIMTNIYLLNLAISDLLFLFTVPFWIHYVLWNEWGFGHCMCKMLSGLYYLALYSEIFFIILLTIDRYLAIVHAVLALRARTVTFATITSIITWGFAVLAALPEFIFHESQDNFGDLSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIQLIFVVMIVFFIFWTPYNLVLLLSAFHSTFLETSCQQSIHLDLAMQVTEVITHTHCCINPIIYAFVGERFRKHLRLFFHRNVAIYLRKYISFLPGEKLERTSSVSPSTGEQEISVVF
  
Inhibitor
Name:
BDBM50041182
Synonyms:
CHEMBL3355940
Type:
Small organic molecule
Emp. Form.:
C25H30F2N2OS
Mol. Mass.:
444.58
SMILES:
COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1
Structure:
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