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Target
KiSS-1 receptor
Ligand
BDBM50045502
Substrate
n/a
Meas. Tech.
ChEMBL_1448383
EC50
32±n/a nM
Citation
 Asami, T; Nishizawa, N; Matsui, H; Takatsu, Y; Suzuki, A; Kiba, A; Terada, M; Nishibori, K; Nakayama, M; Ban, J; Matsumoto, S; Tarui, N; Ikeda, Y; Yamaguchi, M; Kusaka, M; Ohtaki, T; Kitada, C Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity. J Med Chem 57:6105-15 (2014) [PubMed]  Article  BDB Entry
Target
Name:
KiSS-1 receptor
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
42915.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1448383
Residue:
396
Sequence:
MAAEATLGPNVSWWAPSNASGCPGCGVNASDGPGSAPRPLDAWLVPLFFAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVLALHRLSPGPHTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCGPQRQRRPHASAHSDRAAPHSVPHSRAAHPVRVRTPEPGNPVRRSPSVQDEHTAPL
  
Inhibitor
Name:
BDBM50045502
Synonyms:
CHEMBL3314219
Type:
Small organic molecule
Emp. Form.:
C58H78N16O12
Mol. Mass.:
1191.3399
SMILES:
CNC(=N)NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccncc1)NC(=O)[C@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r|
Structure:
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