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Target
Neuromedin-U receptor 2
Ligand
BDBM50049423
Substrate
n/a
Meas. Tech.
ChEMBL_1454701 (CHEMBL3362620)
EC50
8.4±n/a nM
Citation
 Takayama, K; Mori, K; Taketa, K; Taguchi, A; Yakushiji, F; Minamino, N; Miyazato, M; Kangawa, K; Hayashi, Y Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2. J Med Chem 57:6583-93 (2014) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 2
Synonyms:
G-protein coupled receptor FM-4 | G-protein coupled receptor TGR-1 | NMU-R2 | NMU2R | NMU2R | NMUR2 | NMUR2_HUMAN | Neuromedin-U receptor 2 | TGR1
Type:
PROTEIN
Mol. Mass.:
47710.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103075
Residue:
415
Sequence:
MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
  
Inhibitor
Name:
BDBM50049423
Synonyms:
CHEMBL3315278
Type:
Small organic molecule
Emp. Form.:
C45H68N14O8
Mol. Mass.:
933.1104
SMILES:
CC(C)C[C@H](NC(=O)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure:
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