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Target
Prostaglandin E synthase
Ligand
BDBM50443822
Substrate
n/a
Meas. Tech.
ChEMBL_1455679 (CHEMBL3366024)
IC50
400±n/a nM
Citation
 Hanke, T; Lamers, C; Gomez, RC; Schneider, G; Werz, O; Schubert-Zsilavecz, M Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/ activation and dual 5-LO/mPGES-1 inhibition. Bioorg Med Chem Lett 24:3757-63 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
Prostaglandin E2 synthase-1 ( mPGES-1) | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | PTGES_HUMAN | PTGES | MGST1L1 | MPGES1 | PGES | PIG12 | Prostaglandin E synthase/G/H synthase 2
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Human
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50443822
Synonyms:
CHEMBL3094418
Type:
Small organic molecule
Emp. Form.:
C25H29ClN4O2S2
Mol. Mass.:
517.11
SMILES:
CCCCCCC(Sc1nc(Cl)cc(Nc2nc(cs2)-c2ccc3CCCCc3c2)n1)C(O)=O
Structure:
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