Reaction Details Report a problem with these data
Target
Activin receptor type-1
Ligand
BDBM102619
Substrate
n/a
Meas. Tech.
ChEMBL_1453224 (CHEMBL3365517)
IC50
230±n/a nM
Citation
Mohedas, AH; Wang, Y; Sanvitale, CE; Canning, P; Choi, S; Xing, X; Bullock, AN; Cuny, GD; Yu, PB Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem 57:7900-15 (2014) [PubMed] Article
More Info.:
Target
Name:
Activin receptor type-1
Synonyms:
ACVR1_MOUSE | ALK2 | ActR-I | ActRIA | Acvr | Acvr1 | Acvrlk2 | Tgfb1
Type:
Protein
Mol. Mass.:
57231.35
Organism:
Mouse
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC