Reaction Details Report a problem with these data
Target
Activin receptor type-1
Ligand
BDBM102619
Substrate
n/a
Meas. Tech.
ChEMBL_1453218 (CHEMBL3365511)
IC50
420±n/a nM
Citation
 Mohedas, AH; Wang, Y; Sanvitale, CE; Canning, P; Choi, S; Xing, X; Bullock, AN; Cuny, GD; Yu, PB Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem 57:7900-15 (2014) [PubMed]  Article 
Target
Name:
Activin receptor type-1
Synonyms:
Acvr | ActR-I | ActRIA | ACVR1_MOUSE | Acvr1 | Acvrlk2 | Tgfb1 | ALK2
Type:
Protein
Mol. Mass.:
57231.35
Organism:
Mouse
Description:
n/a
Residue:
509
Sequence:
MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM102619
Synonyms:
K02288a | US10688093, Compound 382_0087_0284 | US11701353, Compound 382_0087_0284
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: