Reaction Details Report a problem with these data
Target
SRSF protein kinase 1
Ligand
BDBM50168247
Substrate
n/a
Meas. Tech.
ChEMBL_1455915 (CHEMBL3365346)
IC50
40±n/a nM
Citation
 Ajani, OO Present status of quinoxaline motifs: excellent pathfinders in therapeutic medicine. Eur J Med Chem 85:688-715 (2014) [PubMed]  Article 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Human
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM50168247
Synonyms:
2,3-Di-thiophen-2-yl-benzo[g]quinoxaline-7-carboxylic acid | CHEMBL426445
Type:
Small organic molecule
Emp. Form.:
C21H12N2O2S2
Mol. Mass.:
388.462
SMILES:
OC(=O)c1ccc2cc3nc(-c4cccs4)c(nc3cc2c1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: