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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50062514
Substrate
n/a
Meas. Tech.
ChEMBL_1462845 (CHEMBL3399719)
EC50
5200±n/a nM
Citation
 Piemontese, L; Fracchiolla, G; Carrieri, A; Parente, M; Laghezza, A; Carbonara, G; Sblano, S; Tauro, M; Gilardi, F; Tortorella, P; Lavecchia, A; Crestani, M; Desvergne, B; Loiodice, F Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptora/¿ ligand LT175. Eur J Med Chem 90:583-94 (2015) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50062514
Synonyms:
CHEMBL3397560
Type:
Small organic molecule
Emp. Form.:
C17H17NO4
Mol. Mass.:
299.3212
SMILES:
C\C(=N/O)c1ccc(OC(Cc2ccccc2)C(O)=O)cc1
Structure:
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