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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50063490
Substrate
n/a
Meas. Tech.
ChEMBL_1463123 (CHEMBL3399106)
IC50
690±n/a nM
Citation
 Zhang, H; Ding, CZ; Lai, Z; Chen, SS; Devasthale, P; Herpin, T; Morton, G; Qu, F; Ryono, D; Smirk, R; Wang, W; Wu, S; Ye, XX; Li, YX; Apedo, A; Farrelly, D; Wang, T; Gu, L; Morgan, N; Flynn, N; Chu, C; Kunselman, L; Lippy, J; Locke, K; O'Malley, K; Harrity, T; Cap, M; Zhang, L; Hosagrahara, V; Kadiyala, P; Xu, C; Doweyko, AM; Zahler, R; Hariharan, N; Cheng, PT Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARa/¿ agonists. Bioorg Med Chem Lett 25:1196-205 (2015) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50063490
Synonyms:
CHEMBL3398458
Type:
Small organic molecule
Emp. Form.:
C28H32N2O6
Mol. Mass.:
492.5635
SMILES:
CCOC(=O)N1C[C@@H](CCc2ccc(OCCc3nc(oc3C)-c3ccccc3)cc2)[C@H](C1)C(O)=O |r|
Structure:
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