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Target
Cysteinyl leukotriene receptor 2
Ligand
BDBM50066942
Substrate
n/a
Meas. Tech.
ChEMBL_1466141 (CHEMBL3404759)
IC50
5.7±n/a nM
Citation
 Itadani, S; Takahashi, S; Ima, M; Sekiguchi, T; Aratani, Y; Egashira, H; Matsumura, N; Inoue, A; Yonetomi, Y; Fujita, M; Nakayama, Y; Takeuchi, J Discovery of a potent, orally available dual CysLT1 and CysLT2 antagonist with dicarboxylic acid. Bioorg Med Chem 23:2079-97 (2015) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50066942
Synonyms:
CHEMBL3401691
Type:
Small organic molecule
Emp. Form.:
C36H37N3O8S
Mol. Mass.:
671.759
SMILES:
OC(=O)CCCN1CC(Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc12)C(=O)NS(=O)(=O)c1ccccc1
Structure:
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