Reaction Details Report a problem with these data
Target
Carbonic anhydrase
Ligand
BDBM10885
Substrate
n/a
Meas. Tech.
ChEMBL_1466707 (CHEMBL3404500)
Ki
31±n/a nM
Citation
Syrjänen, L; Kuuslahti, M; Tolvanen, M; Vullo, D; Parkkila, S; Supuran, CT Theß-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides. Bioorg Med Chem 23:2303-9 (2015) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase
Synonyms:
Carbonate dehydratase | Carbonic anhydrase
Type:
PROTEIN
Mol. Mass.:
29919.95
Organism:
Anopheles gambiae
Description:
ChEMBL_109570
Residue:
255
Sequence:
MERILRGVMRYRHTTREQMVQEFRKVRDNPQPKAVFFTCMDSRMIPTRFTETHVGDMFVVRNAGNLVPHAEHFQDEYFSCEPAALELGCVVNNIKHIIVCGHSDCKAMNLLYKLKDPEFASLDNRRISPLRAWLCEHANTSLAKFQNLKEIGLDKPLIFSSETPLRKFVAYIDPENNFAIEDKLSQVNTLQQIENVASYGFLKRRLESHDLHIHALWFDIYTGDIYFFSRNSKRFIAIDESSIDRLLDEVRRYYS
Inhibitor
Name:
BDBM10885
Synonyms:
(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide | (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide | AL-4862 | Azopt | Brinzolamide (BRZ) | brinzolamide
Type:
Small organic molecule
Emp. Form.:
C12H21N3O5S3
Mol. Mass.:
383.507
SMILES:
CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|