Reaction Details Report a problem with these data
Target
Carbonic anhydrase
Ligand
BDBM50427222
Substrate
n/a
Meas. Tech.
ChEMBL_1466707 (CHEMBL3404500)
Ki
6.1±n/a nM
Citation
 Syrjänen, L; Kuuslahti, M; Tolvanen, M; Vullo, D; Parkkila, S; Supuran, CT Theß-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides. Bioorg Med Chem 23:2303-9 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase
Synonyms:
Carbonate dehydratase | Carbonic anhydrase
Type:
PROTEIN
Mol. Mass.:
29919.95
Organism:
Anopheles gambiae
Description:
ChEMBL_109570
Residue:
255
Sequence:
MERILRGVMRYRHTTREQMVQEFRKVRDNPQPKAVFFTCMDSRMIPTRFTETHVGDMFVVRNAGNLVPHAEHFQDEYFSCEPAALELGCVVNNIKHIIVCGHSDCKAMNLLYKLKDPEFASLDNRRISPLRAWLCEHANTSLAKFQNLKEIGLDKPLIFSSETPLRKFVAYIDPENNFAIEDKLSQVNTLQQIENVASYGFLKRRLESHDLHIHALWFDIYTGDIYFFSRNSKRFIAIDESSIDRLLDEVRRYYS
  
Inhibitor
Name:
BDBM50427222
Synonyms:
CHEMBL2324864
Type:
Small organic molecule
Emp. Form.:
C15H17N3O7S2
Mol. Mass.:
415.441
SMILES:
NS(=O)(=O)c1ccc(CCNS(=O)(=O)c2ccc(cc2CO)[N+]([O-])=O)cc1
Structure:
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