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Target
Aldo-keto reductase family 1 member B7
Ligand
BDBM16452
Substrate
n/a
Meas. Tech.
ChEMBL_1475204 (CHEMBL3424959)
IC50
49±n/a nM
Citation
 Stefek, M; Soltesova Prnova, M; Majekova, M; Rechlin, C; Heine, A; Klebe, G Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. J Med Chem 58:2649-57 (2015) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B7
Synonyms:
Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1 | ALD1_RAT | Akr1b7 | Akr1b14
Type:
PROTEIN
Mol. Mass.:
36127.39
Organism:
Rat
Description:
ChEMBL_109605
Residue:
316
Sequence:
MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY
  
Inhibitor
Name:
BDBM16452
Synonyms:
(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Xedia | CHEMBL10372 | Alond | Zopolrestat
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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