Reaction Details Report a problem with these data
Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM50080820
Substrate
n/a
Meas. Tech.
ChEMBL_1475234 (CHEMBL3425032)
Kd
1.7±n/a nM
Citation
 Waterson, AG; Kennedy, JP; Patrone, JD; Pelz, NF; Feldkamp, MD; Frank, AO; Vangamudi, B; Souza-Fagundes, EM; Rossanese, OW; Chazin, WJ; Fesik, SW Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett 6:140-5 (2015) [PubMed]  Article 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
Single-stranded DNA-binding protein | RF-A protein 1 | RP-A p70 | Replication factor A protein 1 | RFA1_HUMAN | RPA1 | REPA1 | RPA70
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Human
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM50080820
Synonyms:
CHEMBL3422476
Type:
Small organic molecule
Emp. Form.:
C28H18Cl3N3O3S
Mol. Mass.:
581.01
SMILES:
OC(=O)c1ccc(o1)-c1ccc(C(=S)NCc2ccc(cc2)-c2ccnn2-c2ccc(Cl)c(Cl)c2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: